Apoptosis Reagents and Kits
Abcam Human SQSTM1 (p62) knockout HEK-293T cell lysate.
Human SQSTM1 (p62) knockout HEK-293T cell lysate.
The product is subject to the following: Abcam Restricted Use Statement
Abcam Human VIM (Vimentin) knockout HeLa cell lysate.
Human VIM (Vimentin) knockout HeLa cell lysate.
The product is subject to the following: Abcam Restricted Use Statement
Abcam Human APP (Amyloid Precursor Protein) knockout HEK-293T cell lysate.
Human APP (Amyloid Precursor Protein) knockout HEK-293T cell lysate.
The product is subject to the following: Abcam Restricted Use Statement
Abcam Human HMGB1 knockout HeLa cell lysate.
Human HMGB1 knockout HeLa cell lysate.
The product is subject to the following: Abcam Restricted Use Statement
Abcam Human CTNNB1 (beta Catenin) knockout HeLa cell lysate.
Human CTNNB1 (beta Catenin) knockout HeLa cell lysate.
The product is subject to the following: Abcam Restricted Use Statement
Abcam Cathepsin D Inhibitor Assay¿Kit
Cathepsin D Inhibitor Assay¿Kit
The product is subject to the following: Abcam Restricted Use Statement
Biolegend Apotracker™ Tetra Alexa Fluor 647; Reactivity: Human, Mouse; Apps: FC; Size: 100 tests
Apotracker™ Tetra Alexa Fluor 647; Reactivity: Human, Mouse; Apps: FC; Size: 100 tests
Biotium Mitochondrial Marker113-1 Biotin conjugate 0.1mgmL
Mitochondrial Marker113-1 Biotin conjugate 0.1mgmL
Biotium Mitochondrial MarkerMTC02 Biotin conjugate 0.1mgmL
Mitochondrial MarkerMTC02 Biotin conjugate 0.1mgmL
AdipoGen SP600125
Chemical. CAS 129-56-6. Formula C14H8N2O. MW 220.2. SP600125 is an orally active, reversible and ATP-competitive broad-spectrum JNK inhibitor for JNK1, JNK2 and JNK3 IC50 = 40nM, 40nM and 90nM, respectively. In Jurkat T cells, SP600125 suppressed the phosphorylation of c-Jun with IC50 of 5-10 µM. It has 10-fold greater selectivity against MKK4, 25-fold greater selectivity against MKK3, MKK6, PKB and PKCalpha, and 100-fold selectivity against ERK2, p38, Chk1, EGFR. SP600125 is also a broad-spectrum inhibitor of serine/threonine kinases including hydrocarbon receptor AhR, Mps1, Aurora kinase A, FLT3 and TRKA. SP600125 inhibits cell cycle, autophagy and ferroptosis and activates apoptosis. It shows anti-inflammatory activity by inhibiting the expression of inflammatory genes such as COX-2, IL-2 IFN-gamma and TNF-alpha and has antiviral and neuroprotective properties.
AdipoGen CRT0066101 HCl
Chemical. CAS 1781742-22-0. Formula C18H22N6O . 3HCl. MW 338.4 . 109.4. CRT0066101 is an inhibitor of all three PKD isoforms IC50s = 1, 2.5, and 2 nM for PKD1, PKD2 and PKD3, respectively. It exhibits selectivity for PKD against a panel of >90 protein kinases, including PKCalpha, PKBalpha, MEK, ERK, c-Raf, c-Src and c-Abl. PKD family members play an important role in regulating several cellular processes and activities, including chromatin organization, Golgi function, gene expression, cell survival, adhesion, motility, differentiation, DNA synthesis and proliferation. CRT0066101 shows anticancer activity by blocking cell proliferation, inducing apoptosis, G2/M phase arrest, inhibiting migration and invasion and reducing the viability of several cancer cells both in vitro and in vivo.
AdipoGen RBN-2397
Chemical. CAS 2381037-82-5. Formula C20H23F6N7O3. MW 523.4. RBN-2397 is a potent NAD competitive small molecule inhibitor of PARP-7. RBN-2397 selectively inhibits PARP-7 and demonstrates >50-fold selectivity for inhibition of PARP-7 over all PARP family members as measured by biochemical assays. RBN-2397 inhibits PARP-7-dependent MARylation IC50 = 2nM in cell biochemical assay and inhibits cells proliferation in NCI-H1373 lung cancer cells IC50 = 20nM. By selectively inhibiting PARP-7 in tumor cells, RBN-2397 has been shown to directly inhibit cellular proliferation and restore Type I interferon signaling to stimulate an innate and adaptive antitumor immune response. Targeting cytosolic nucleic acid sensing pathways and the Type I interferon IFN response is an emerging therapeutic strategy being explored in oncology. The PARP family consists of seventeen enzymes that regulate fundamental biological processes including response to cellular stress.